Why the study?
Does methoxyflurane cause dose-related nephrotoxicity compared to halothane in patients undergoing anesthesia?
Population
26 patients undergoing anesthesia (18 receiving methoxyflurane, 8 controls)
Comparison
Methoxyflurane with usual anesthetic adjuvants vs Halothane
Design
Cohort
Authors
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Methoxyflurane was associated with dose-related renal dysfunction; leaves open whether dose limits are warranted pending randomized data.
Does methoxyflurane cause dose-related nephrotoxicity compared to halothane in patients undergoing anesthesia?
Methoxyflurane induces dose-dependent nephrotoxicity, indicating its clinical use should be restricted to situations where dosages less than 2.5 MAC hours can be maintained.
M. J. Cousins (1973) studied this question.
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