Why the study?
Are elevated fluoride concentrations associated with nephrotoxic effects following methoxyflurane anesthesia?
Are elevated fluoride concentrations associated with nephrotoxic effects following methoxyflurane anesthesia?
Nephrotoxicity following methoxyflurane anesthesia appears to be driven by prolonged elevation of inorganic fluoride due to the breakdown of nonvolatile organic fluoride and poor renal clearance.
May link fluoride elevation to methoxyflurane nephrotoxicity; hypothesis-generating case report leaves causal role open.
The concentrations of inorganic fluoride and nonvolatile organic fluoride were measured in a patient with nephrotoxic effects following methoxyflurane anesthesia. Concentrations of both were markedly elevated compared to two patients who received methoxyflurane without subsequent nephrotoxic effects. Indirect evidence suggests that the inorganic fluoride concentration was sufficient to account for the nephrotoxic effects. The prolonged elevation of inorganic fluoride observed can be explained on the basis of the breakdown of the nonvolatile organic fluoride to inorganic fluoride and the poor renal clearance of both types.
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Donald R. Taves (1970) studied this question.
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