Why the study?
Does methoxyflurane cause dose-related nephrotoxicity compared to halothane in patients undergoing anesthesia?
Does methoxyflurane cause dose-related nephrotoxicity compared to halothane in patients undergoing anesthesia?
Methoxyflurane causes dose-dependent nephrotoxicity, suggesting its clinical use should be restricted to specific situations with dosages less than 2.5 MAC hours.
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Methoxyflurane was associated with dose-related renal abnormalities; leaves open causality and dosing limits pending randomized confirmation.
Michael J. Cousins (1973) studied this question.
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