Key result
Motion artefact during ischemia becomes substantial after approximately two minutes, decreases with time and repeated ischemia, and exhibits an unpredictable shape dependent on the individual rabbit.
In isolated rabbit hearts, motion artefacts in optical action potential recordings become substantial 2 minutes after ischemia onset and decrease with repeated ischemic episodes, highlighting the need for dynamic artefact suppression methods.
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May confound prolonged optical mapping in ischemia; leaves open need for dynamic correction algorithms in translational models.
Motion artefact (MA) in voltage-sensitive fluorescent signals causes significant debasement of action potential. During ischemia and reperfusion in isolated rabbit heart, this artefact develops in a manner which may be described by the time of its onset, level, and shape. The MA during ischemia: (a) may become substantial with approximately two minutes delay after establishing global ischemia; (b) may be almost twice as high as the physiological action potential and decreases both with time and repetition of ischemia; (c) the MA shape is unpredictable and depends on individual rabbit.
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Janoušek et al. (2013) studied Ischemia (n=12). Repeated global ischemia vs. Control period and reperfusion was evaluated on Motion artefact (MA) mass and maximum. Motion artefact during ischemia becomes substantial after approximately two minutes, decreases with time and repeated ischemia, and exhibits an unpredictable shape dependent on the individual rabbit.
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