Key result
DAPT is linked to ~9% minor bleeding, predicted by older age, anemia, and PRECISE-DAPT ≥25.
Why the study?
Although prasugrel and ticagrelor are preferred in ACS, clopidogrel remains the most widely used DAPT agent despite bleeding risks.
Observational (n=187)
Yes
In patients undergoing PCI, a 12-month duration of DAPT with clopidogrel is associated with increased minor bleeding events, particularly in those with a PRECISE-DAPT score ≥25, highlighting the need for individualized therapy duration.
Minor bleeding on DAPT associates with older age, anemia, and PRECISE-DAPT ≥25; hypothesis-generating for score-guided duration but should not yet change practice.
In patients with coronary artery disease, percutaneous coronary interventions (PCI) are the mainstay of treatment for those presenting with acute coronary syndrome (ACS); PCI has also been widely adopted in patients with chronic coronary syndromes. Adjuvant pharmacotherapy, especially antithrombotic therapy, is the key to reducing local thrombotic complications and systemic ischemic events among patients undergoing percutaneous coronary interventions, but is inevitably associated with the occurrence of bleeding events. Prasugrel and ticagrelor are preferred over clopidogrel in patients with ACS in the absence of contraindications. Despite this, clopidogrel remains the most widely used. In this article, the bleeding events that occurred during 6-12 months of dual antiplatelet therapy (aspirin + P2Y12 inhibitor - clopidogrel) in patients who underwent myocardial revascularization by PCI, the factors that favored their occurrence and the use of the prediction score were studied.
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Dogot et al. (2023) conducted an observational in Coronary artery disease requiring dual antiplatelet therapy (n=187). Dual antiplatelet therapy (aspirin + clopidogrel) was evaluated on Bleeding events. During 6-12 months of dual antiplatelet therapy with aspirin and clopidogrel, minor bleeding events occurred in 9.09% of patients, with older age, anemia, and a PRECISE-DAPT score ≥25 identified as significant predictors.
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