Why the study?
Does oral pleconaril reduce day 5 oropharyngeal culture positivity in neonates with suspected enterovirus sepsis?
Population
61 neonates with suspected enterovirus sepsis with onset at ≤15 days of life
Comparison
Oral pleconaril for 7 days vs Placebo for 7 days
Design
RCT, 2:1, Double-blind, placebo-controlled
Follow-up
2 months
Authors
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Supports pleconaril consideration in neonatal enterovirus sepsis despite neutral primary endpoint; extends survival evidence for antivirals.
Does oral pleconaril reduce day 5 oropharyngeal culture positivity in neonates with suspected enterovirus sepsis?
Pleconaril did not reduce day 5 oropharyngeal culture positivity but was associated with improved 2-month survival and faster virologic clearance in neonates with enterovirus sepsis.
Abzug et al. (2015) studied this question.
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