May 18, 2015Journal of the Pediatric Infectious Diseases SocietyOpen Access

Treatment of Neonatal Enterovirus Infections

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Why the study?

Does oral pleconaril improve viral clearance in neonates with severe enterovirus infection?

Population

Neonates with severe enterovirus infection

Comparison

Oral pleconaril vs Placebo (with permitted concurrent use of IVIG)

Design

Editorial, placebo-controlled

Authors

JMJohn F. ModlinDartmouth College

Discussion

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Implication

Despite early termination, the trial provides clinically meaningful evidence that pleconaril may accelerate viral clearance and potentially improve survival in neonates with severe enterovirus infections.

Structured PICO

Does oral pleconaril improve viral clearance in neonates with severe enterovirus infection?

Population

Neonates with severe enterovirus infection

Intervention

Oral pleconaril (with permitted concurrent use of IVIG)

Comparator

Placebo (with permitted concurrent use of IVIG)

Outcome

Oropharyngeal viral cultures after 5 days of treatmentsurrogate

Limitations

Infrequent occurrence of disease in newborns
Difficulty in obtaining parental consent for a placebo-controlled study of a potentially fatal infectious disease
Study discontinued after 11 years due to expiration of available drug supply before reaching accrual target
Primary endpoint could not be assessed because oropharyngeal viral cultures were negative for all enrolled infants after 5 days of treatment

Cite This Study

John F. Modlin (2015) studied this question.

synapsesocial.com/papers/6a832516f71f34e1aae8ebbb https://doi.org/10.1093/jpids/piv030

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Treatment of Neonatal Enterovirus Infections

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Treatment of Neonatal Enterovirus Infections

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider