Key result
Enterovirus 71 infection was endemic in the US from 1977-1991, with a peak of 45 cases in 1987, of which 60% presented with severe neurologic disease.
Observational (n=193)
Yes
Enterovirus 71 has been endemic in the United States since at least 1977 and continues to be an occasional cause of severe neurologic disease, with periodic widespread infection peaks.
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Raises clinician awareness for EV71 in severe neurologic disease; extends historical evidence of US endemicity while leaving current burden open.
Alexander et al. (1994) conducted an observational in Enterovirus 71 infection (n=193). Enterovirus 71 infection was evaluated on Severe neurologic disease. Enterovirus 71 infection was endemic in the US from 1977-1991, with a peak of 45 cases in 1987, of which 60% presented with severe neurologic disease.
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