Key result
Chronic heart rate reduction with ivabradine induced a complex remodeling of ion channel expression in the sinoatrial node but had little impact on transcripts in the ventricle.
Why the study?
Does ivabradine alter ion channel expression in the sinoatrial node and ventricle in 10-week-old male C57BL/6 mice?
Does ivabradine alter ion channel expression in the sinoatrial node and ventricle in 10-week-old male C57BL/6 mice?
Chronic heart rate reduction with ivabradine induces complex remodeling of ion channel expression in the sinoatrial node but has little impact on the ventricle in mice.
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Does not support changing ivabradine use; leaves open translational relevance of SAN remodeling to humans.
Léoni et al. (2005) studied Heart rate reduction effects on ion channel expression. Ivabradine vs. Vehicle was evaluated on Expression of 68 ion channel subunits in the sinoatrial node and ventricle. Chronic heart rate reduction with ivabradine induced a complex remodeling of ion channel expression in the sinoatrial node but had little impact on transcripts in the ventricle.
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