Key result
S16257 administration in conscious rats significantly reduced heart rate, mean arterial blood pressure, and cardiac index compared to vehicle, without signs of negative inotropic action.
Why the study?
Does the novel bradycardic agent S16257 alter cardiac and regional haemodynamics in conscious rats?
Does the novel bradycardic agent S16257 alter cardiac and regional haemodynamics in conscious rats?
The novel bradycardic agent S16257 effectively lowers heart rate without signs of negative inotropic action or impairment of regional perfusion in conscious rats.
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S16257 induces bradycardia with preserved output in rats; leaves open clinical translation pending human studies.
Gardiner et al. (1995) studied this question. S16257 vs. Vehicle (5% dextrose) was evaluated on Cardiac and regional haemodynamics (including heart rate, mean arterial blood pressure, cardiac index). S16257 administration in conscious rats significantly reduced heart rate, mean arterial blood pressure, and cardiac index compared to vehicle, without signs of negative inotropic action.