September 1, 1978
View Full PaperEvolution and Function of the Hla System
Key Points
Key points are not available for this paper at this time.
Abstract
The authors summarize the data on HLA variation in the human population, including particularly associations between alleles at different loci due to linkage disequilibrium, and then try to explain the polymorphism and disease associations in terms of known mechanisms and HLA system functions. Finally, they consider the evolution of the HLA region and the functional significance of such a complex cluster of genes.