Key result
Optimizing transesophageal rapid atrial pacing at twice the threshold improved phenotype discrimination of atrial fibrillation susceptibility in a pacing mode and sex-specific manner in mice.
Why the study?
Methods were needed to optimize transesophageal rapid atrial pacing to detect atrial fibrillation susceptibility in mouse models.
Does optimized transesophageal rapid atrial pacing improve the detection of AF susceptibility in mouse models?
Does optimized transesophageal rapid atrial pacing improve the detection of AF susceptibility in mouse models?
Transesophageal rapid atrial pacing protocols in mice should be individually optimized (e.g., pacing at twice threshold) to accurately detect AF susceptibility and avoid false positives from excessive stimulation.
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Supports protocol optimization for accurate AF phenotyping in mice; leaves open translation to clinical models.
Murphy et al. (2021) studied Atrial fibrillation susceptibility. Optimized transesophageal rapid atrial pacing (RAP) was evaluated on Phenotype discrimination of AF susceptibility. Optimizing transesophageal rapid atrial pacing at twice the threshold improved phenotype discrimination of atrial fibrillation susceptibility in a pacing mode and sex-specific manner in mice.
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