Key result
Transvenous pacing following carbamyl choline injection induced atrial tachycardia and fibrillation in 11 of 14 (78.6%) normal mice, compared to 1 of 14 (7.1%) at baseline.
Why the study?
Does transvenous pacing following cholinergic stimulation induce atrial tachycardia and fibrillation in normal mice?
Population
14 normal mice
Comparison
Transvenous endocardial pacing following… vs Baseline electrophysiology study
Design
Preclinical
Authors
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Supports small-animal AF models; challenges critical mass hypothesis but leaves open human translation.
Does transvenous pacing following cholinergic stimulation induce atrial tachycardia and fibrillation in normal mice?
Absolute Event Rate: 78.6% vs 7.1%
Sustained atrial tachycardia and fibrillation can be reproducibly induced in normal mice using endocardial pacing after cholinergic stimulation, challenging the theory that a critical mass is required.
Hiroko Wakimoto (2001) studied Atrial tachycardia and fibrillation (n=14). Transvenous pacing following carbamyl choline injection vs. Baseline (transvenous pacing without carbamyl choline) was evaluated on Induction of atrial tachycardia and fibrillation. Transvenous pacing following carbamyl choline injection induced atrial tachycardia and fibrillation in 11 of 14 (78.6%) normal mice, compared to 1 of 14 (7.1%) at baseline.
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