Key result
In vivo acoustoelectric cardiac imaging in a swine model measured beat-to-beat variability of the cardiac activation wave peak at 5.32 ± 0.74 µV, 3.26 ± 0.54 mm below the epicardial surface.
In vivo acoustoelectric cardiac imaging successfully mapped cardiac electric spatiotemporal dynamics in a swine model, demonstrating potential utility for guiding electroanatomic mapping during ablation.
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Acoustoelectric imaging maps subsurface activation in swine; leaves open translation to human ablation guidance.
Acoustoelectric cardiac imaging (ACI) is a hybrid modality that exploits the interaction of an ultrasonic pressure wave and the resistivity of tissue to map current densities in the heart. This study demonstrates for the first time in vivo ACI in a swine model. ACI measured beat-to-beat variability ( n = 20 ) of the peak of the cardiac activation wave at one location of the left ventricle as 5.32 ± 0.74 µ V , 3.26 ± 0.54 m m below the epicardial surface, and 2.67 ± 0.56 m s before the peak of the local electrogram. Cross-sectional ACI images exhibited propagation velocities of 0.192 ± 0.061 m / s along the epicardial–endocardial axis with an SNR of 24.9 dB. This study demonstrates beat-to-beat and multidimensional ACI, which might reveal important information to help guide electroanatomic mapping procedures during ablation therapy.
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Alvarez et al. (2020) studied Cardiac electric spatiotemporal dynamics (n=20). Acoustoelectric cardiac imaging (ACI) was evaluated on Beat-to-beat variability of the peak of the cardiac activation wave. In vivo acoustoelectric cardiac imaging in a swine model measured beat-to-beat variability of the cardiac activation wave peak at 5.32 ± 0.74 µV, 3.26 ± 0.54 mm below the epicardial surface.
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