Key result
PCI plus OMT reduces mortality ~52% versus OMT alone in chronic coronary syndrome.
Why the study?
Despite advances in medical therapy and stent technology, the relative efficacy and benefits of PCI versus OMT in chronic coronary syndrome remain under debate.
Does PCI added to optimal medical therapy reduce major adverse cardiac events compared to optimal medical therapy alone in patients with chronic coronary syndrome?
RCT (n=108)
Single-blind
Does PCI added to optimal medical therapy reduce major adverse cardiac events compared to optimal medical therapy alone in patients with chronic coronary syndrome?
Hazard Ratio: 0.477 (95% CI 0.262–0.869)
p-value: p=0.016
In a small trial of patients with chronic coronary syndrome, PCI added to optimal medical therapy significantly reduced mortality compared to medical therapy alone over 5 years.
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Supports PCI plus OMT to reduce mortality in CCS; challenges consensus from larger negative RCTs.
Moeswir et al. (2025) conducted an RCT in Chronic Coronary Syndrome (n=108). Percutaneous Coronary Intervention (PCI) + Optimal Medical Therapy (OMT) vs. Optimal Medical Therapy (OMT) only was evaluated on Major Adverse Cardiac Events (MACE), including death, stroke, myocardial infarction, and hospitalization due to heart failure (HR 0.477, 95% CI 0.262-0.869, p=0.016). Percutaneous coronary intervention plus optimal medical therapy reduced the risk of death (HR 0.477; 95% CI 0.262-0.869; P=0.016) compared to medical therapy alone in chronic coronary syndrome.
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