Key result
99Tcm-gluconate accumulation in isolated rat cardiac myocytes and hepatocytes during anoxia mimics the in vivo isotope uptake course seen in human myocardial infarction.
Why the study?
Does anoxia affect the accumulation of 99Tcm-gluconate in isolated rat cardiac myocytes and hepatocytes?
Does anoxia affect the accumulation of 99Tcm-gluconate in isolated rat cardiac myocytes and hepatocytes?
The accumulation of 99Tcm-gluconate in anoxic rat cardiac myocytes mimics the in vivo uptake seen in human myocardial infarction, supporting its potential utility as an imaging marker.
99Tcm-gluconate uptake during anoxia parallels human MI patterns; leaves open its viability as an imaging marker pending clinical studies.
The accumulation of 99Tcm-gluconate in the myocardium and liver of the rat during anoxia has been investigated on the cellular level and compared with the histopathologic changes. The conclusion is drawn that the uptake of isotope runs a course similar to that registered in vivo in human myocardial infarction.
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Rajs et al. (1979) studied this question. 99Tcm-gluconate accumulation in isolated rat cardiac myocytes and hepatocytes during anoxia mimics the in vivo isotope uptake course seen in human myocardial infarction.
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