Key result
Congestive heart failure was not associated with reduced inhibition of platelet aggregation by sodium nitroprusside compared to controls.
Why the study?
Does chronic heart failure alter platelet responsiveness to nitric oxide compared to normal subjects?
Observational
Does chronic heart failure alter platelet responsiveness to nitric oxide compared to normal subjects?
Subsets of CHF patients exhibit platelet resistance to nitric oxide, which correlates with increasing age and oxidative stress.
Answers are grounded in this paper and cite their sources.
No overall platelet NO resistance in CHF; leaves open subset effects tied to age and oxidative stress.
Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p<0.05).
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Anderson et al. (2003) conducted an observational in Congestive heart failure. Congestive heart failure vs. Normal subjects was evaluated on Inhibition of platelet aggregation by sodium nitroprusside (p=ns). Congestive heart failure was not associated with reduced inhibition of platelet aggregation by sodium nitroprusside compared to controls.
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