Key result
Low molecular weight heparin demonstrated similar efficacy and safety compared to unfractionated heparin for the treatment and prophylaxis of pulmonary embolism.
Why the study?
Does low molecular weight heparin improve efficacy and safety compared to unfractionated heparin in patients with pulmonary embolism?
Does low molecular weight heparin improve efficacy and safety compared to unfractionated heparin in patients with pulmonary embolism?
Low molecular weight heparin is as effective and safe as unfractionated heparin for the management and prophylaxis of pulmonary embolism.
Answers are grounded in this paper and cite their sources.
Supports LMWH as alternative to UFH for PE; leaves open need for RCTs to confirm.
Anticoagulation is the mainstay treatment of pulmonary embolism. Using low molecular weight heparin versus unfractionated heparin remains a matter of debate. Objectives: the aim of this review is to study the prognosis of using low molecular weight versus unfractionated heparin in treatment of pulmonary embolism. Methods: PubMed and Cochrane library were searched for articles comparing the efficacy of low molecular weight heparin and unfractionated heparin in management of pulmonary embolism. Ten related results were selected for review. Results: Literatures studies indicated that low molecular weight heparin was effective in therapeutic treatment of acute sub-massive and massive pulmonary embolism. It was as effective as intravenous unfractionated heparin. It was not associated with higher risk of major, minor bleeding, or thrombocytopenia. Low molecular weight heparin was as effective as unfractionated heparin in prophylaxis of deep venous sinus thrombosis as well as pulmonary embolism. Discussion: Low-molecular-weight heparin seemed to be as effective safe as intravenous unfractionated heparin for the treatment as well as prophylaxis of pulmonary embolism. It was also safe with no major bleeding risk or higher risk of thrombocytopenia. Conclusion: Both low molecular weight and unfractionated heparin had similar efficacy and safety in management of PE.
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Binobaid et al. (2017) conducted a review in Pulmonary embolism. Low molecular weight heparin vs. Unfractionated heparin was evaluated on Efficacy and safety in management of pulmonary embolism. Low molecular weight heparin demonstrated similar efficacy and safety compared to unfractionated heparin for the treatment and prophylaxis of pulmonary embolism.
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