Key result
In hypertrophic rat hearts induced by aortic banding, unloaded myocyte contraction was depressed, and reduction of extracellular Ca to 0.5 mM unmasked a depressed fractional SR Ca release.
In a rat model of left ventricular hypertrophy, unloaded myocyte contraction is depressed and fractional SR Ca release is impaired under reduced extracellular calcium conditions.
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Impaired SR Ca release may underlie myocyte dysfunction in hypertrophy; hypothesis-generating for human HF mechanisms.
McCall et al. (1998) studied Left ventricular hypertrophy. Abdominal aorta banding vs. Sham was evaluated on Ca flux, contractility, and excitation-contraction coupling. In hypertrophic rat hearts induced by aortic banding, unloaded myocyte contraction was depressed, and reduction of extracellular Ca to 0.5 mM unmasked a depressed fractional SR Ca release.
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