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March 10, 2010AJP Endocrinology and Metabolism

L-arginine decreased RVSP, right heart hypertrophy, mortality, and pulmonary artery wall thickness while increasing NO production, eNOS expression, phosphorylation, and association with HSP90.

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Why the study?

Does L-arginine improve hemodynamics and survival in monocrotaline-induced pulmonary hypertension in rats?

Population

Sprague Dawley rats treated with monocrotaline (MCT)

Comparison

L-arginine for 3 or 5 weeks vs Monocrotaline (MCT) without L-arginine

Design

Preclinical

Follow-up

3 or 5 weeks

Authors

ZOZhi‐Jun OuWWWei WeiDHDa-de Huang

Discussion

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Overview

Hypothesis-generating for L-arginine in experimental pulmonary hypertension; leaves open translation to human disease.

Structured PICO

Does L-arginine improve hemodynamics and survival in monocrotaline-induced pulmonary hypertension in rats?

P
Population
Sprague Dawley rats treated with monocrotaline (MCT)
I
Intervention
L-arginine for 3 or 5 weeks
C
Comparator
Monocrotaline (MCT) without L-arginine
O
Outcome
Right ventricular systolic pressure (RVSP), right heart hypertrophy, survival rate, pulmonary artery wall thickness, nitric oxide (NO) concentration, and superoxide anion generationsurrogate

L-arginine attenuates monocrotaline-induced pulmonary hypertension in rats by restoring eNOS expression, phosphorylation, and coupling with HSP90.

Cite This Study

Ou et al. (2010) studied this question.

synapsesocial.com/papers/6a2241bb00d082f62f9723bbhttps://doi.org/10.1152/ajpendo.00107.2010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats2007 · 61 citations
  2. 2Chronic <scp>l</scp> -Arginine Administration Attenuates Cardiac Hypertrophy in Spontaneously Hypertensive Rats1996 · 117 citations
  3. 3Chronic l-arginine treatment increases cardiac cyclic guanosine 5′-monophosphate in rats with aortic stenosis: effects on left ventricular mass and beta-adrenergic contractile reserve1998 · 14 citations
  4. 4Increased<scp>l</scp>-arginine uptake and inducible nitric oxide synthase activity in aortas of rats with heart failure2001 · 40 citations
  5. 5Effect of Oral L-Arginine Administration for Three Weeks in Two Kidney-two Clip Hypertensive Rats2000 · 12 citations