August 1, 1998Journal of the American College of CardiologyOpen Access

L-arginine treatment led to a 1.7-fold increase in LV cyclic GMP levels (p < 0.05) but did not suppress LVH and depressed in vivo LV systolic pressure (163 +/- 16 vs 198 +/- 10 mm Hg, p < 0.05).

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Why the study?

Does L-arginine increase cardiac cyclic GMP and modify left ventricular hypertrophy and beta-adrenergic contractile response in rats with aortic stenosis?

Population

80 rats (40 control rats and 40 rats with aortic stenosis left ventricular hypertrophy)

Comparison

L-arginine (0.40 g/kg/day) for 6 weeks vs No drug for 6 weeks

Design

Preclinical, randomized

Follow-up

6 weeks

Authors

JBJozef Bartúnek SDStephen Dempsey EWEllen O. Weinberg

Discussion

Member takes

Overview

L-arginine may worsen LV systolic function despite raising cGMP in pressure overload; leaves open whether cGMP augmentation can regress LVH in humans.

Structured PICO

Does L-arginine increase cardiac cyclic GMP and modify left ventricular hypertrophy and beta-adrenergic contractile response in rats with aortic stenosis?

Population

80 rats (40 control rats and 40 rats with aortic stenosis left ventricular hypertrophy)

Intervention

L-arginine (0.40 g/kg/day) for 6 weeks

Comparator

No drug for 6 weeks

Outcome

Cardiac cyclic GMP production, left ventricular mass/hypertrophy, and beta-adrenergic contractile responsesurrogate

In a rat model of aortic stenosis, chronic L-arginine increased cardiac cGMP but failed to reduce hypertrophy and worsened LV systolic function and contractile reserve.

Cite This Study

Bartúnek et al. (1998) studied this question.

synapsesocial.com/papers/6a71ff4926a7f98052de14df https://doi.org/10.1016/s0735-1097(98)00262-9

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August 1, 1998Journal of the American College of CardiologyOpen Access

L-arginine treatment led to a 1.7-fold increase in LV cyclic GMP levels (p < 0.05) but did not suppress LVH and depressed in vivo LV systolic pressure (163 +/- 16 vs 198 +/- 10 mm Hg, p < 0.05).

View Full Paper

Ask AI

Bookmark

Why the study?

Does L-arginine increase cardiac cyclic GMP and modify left ventricular hypertrophy and beta-adrenergic contractile response in rats with aortic stenosis?

Population

80 rats (40 control rats and 40 rats with aortic stenosis left ventricular hypertrophy)

Comparison

L-arginine (0.40 g/kg/day) for 6 weeks vs No drug for 6 weeks

Design

Preclinical, randomized

Follow-up

6 weeks

Authors

JBJozef Bartúnek SDStephen Dempsey EWEllen O. Weinberg

Discussion

Member takes

Overview

L-arginine may worsen LV systolic function despite raising cGMP in pressure overload; leaves open whether cGMP augmentation can regress LVH in humans.

Structured PICO

Does L-arginine increase cardiac cyclic GMP and modify left ventricular hypertrophy and beta-adrenergic contractile response in rats with aortic stenosis?

Population

80 rats (40 control rats and 40 rats with aortic stenosis left ventricular hypertrophy)

Intervention

L-arginine (0.40 g/kg/day) for 6 weeks

Comparator

No drug for 6 weeks

Outcome

Cardiac cyclic GMP production, left ventricular mass/hypertrophy, and beta-adrenergic contractile responsesurrogate

In a rat model of aortic stenosis, chronic L-arginine increased cardiac cGMP but failed to reduce hypertrophy and worsened LV systolic function and contractile reserve.

Cite This Study

Bartúnek et al. (1998) studied this question.

synapsesocial.com/papers/6a71ff4926a7f98052de14df https://doi.org/10.1016/s0735-1097(98)00262-9

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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