Key result
Stage 3 hypertension at diagnosis was associated with a higher risk of cardiovascular mortality compared to stage 1, with a stronger effect in patients aged 60-69 years (HR 1.56 in males, HR 1.48 in females) than in those aged 70-85 years.
Why the study?
Little is known regarding the age-specific association of hypertension stage at diagnosis with cardiovascular or all-cause mortality among elderly patients.
Does stage 3 hypertension at diagnosis increase cardiovascular and all-cause mortality compared to stage 1 hypertension in elderly patients?
Cohort (n=125,978)
Does stage 3 hypertension at diagnosis increase cardiovascular and all-cause mortality compared to stage 1 hypertension in elderly patients?
Hazard Ratio: 1.56 (95% CI 1.41–1.72)
Stage 3 hypertension at diagnosis is associated with a higher risk of cardiovascular and all-cause mortality in elderly patients, with a more pronounced relative risk increase in those aged 60-69 compared to those aged 70-85.
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May refine age-specific risk stratification in elderly hypertension; extends observational data but leaves causal effects and intervention benefits open.
Wu et al. (2023) conducted a cohort in Hypertension (n=125,978). Stage 3 hypertension at diagnosis vs. Stage 1 hypertension at diagnosis was evaluated on Cardiovascular mortality (males aged 60-69 years) (HR 1.56, 95% CI 1.41-1.72). Stage 3 hypertension at diagnosis was associated with a higher risk of cardiovascular mortality compared to stage 1, with a stronger effect in patients aged 60-69 years (HR 1.56 in males, HR 1.48 in females) than in those aged 70-85 years.
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