Key result
Hypertension onset at age <35 years was associated with increased odds of left ventricular hypertrophy (OR 2.29; 95% CI 1.36-3.86) and coronary calcification compared to normotension.
Why the study?
Although early onset hypertension increases cardiovascular mortality risk, whether it promotes target end-organ damage by midlife was unknown.
Does early onset hypertension increase the risk of target end-organ damage by midlife in middle-aged adults?
Population
2680 middle-aged CARDIA study participants
Comparison
Hypertension onset age <35, 35-44, ≥45 years vs no hypertension
Design
Cohort study
Authors
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Early-onset hypertension may warrant closer midlife monitoring; leaves open whether earlier intervention prevents target-organ damage.
Cohort (n=2,680)
Does early onset hypertension increase the risk of target end-organ damage by midlife in middle-aged adults?
Odds Ratio: 2.29 (95% CI 1.36–3.86)
Early onset hypertension (before age 35) is significantly associated with the development of target end-organ damage such as left ventricular hypertrophy and coronary calcification by midlife.
Suvila et al. (2019) conducted a cohort in Hypertension (n=2,680). Early onset hypertension (age <35 years) vs. Normotensive individuals was evaluated on Left ventricular hypertrophy (OR 2.29, 95% CI 1.36-3.86). Hypertension onset at age <35 years was associated with increased odds of left ventricular hypertrophy (OR 2.29; 95% CI 1.36-3.86) and coronary calcification compared to normotension.
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