Key result
Early-onset hypertension linked to ~152% greater CKD risk versus no hypertension.
Why the study?
Chronic kidney disease is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD.
Does a younger age of onset of hypertension increase the risk of developing chronic kidney disease?
Cross-Sectional (n=30,613)
Does a younger age of onset of hypertension increase the risk of developing chronic kidney disease?
Effect estimate: OR 2.52 (95% CI 1.53-4.14)
Absolute Event Rate: 21.1% vs 8.9%
p-value: p=<0.001
Early-onset hypertension (before age 35) is strongly and independently associated with an increased risk of developing chronic kidney disease, highlighting the need for aggressive monitoring and management in younger hypertensive patients.
May prompt earlier renal monitoring in young-onset hypertension; hypothesis-generating, needing prospective data before informing practice.
Background Hypertension can damage multiple target organs. The younger the age of onset of hypertension is, the greater the risk of cardiovascular disease (CVD) and cardiovascular death. Chronic kidney disease (CKD) is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD. Objective We investigated the relationship between the age of onset of hypertension and CKD. Method We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2007–2018. A total of 30,613 participants were assigned to one of four groups. Group 1, no hypertension ( n = 19,516); Group 2, age of onset <35 years ( n = 2,180); Group 3, 35≤ age of onset <45 years ( n = 2,128); and Group 4, age of onset ≥45 years ( n = 6,789). Logistic regression analysis was used to evaluate the relationship between the age of onset of hypertension and CKD. Results After adjusting for potential confounders, a younger age at onset of hypertension was associated with a greater risk of developing CKD compared with the absence of hypertension (Group 2 OR: 2.52, 95% CI: 1.53–4.14, P < 0.001; Group 3 OR: 1.59, 95% CI: 1.01–2.51, P = 0.048; Group 4 OR: 1.54, 95% CI: 1.00–2.38, P = 0.050). Conclusions There was a strong association between the age of onset of hypertension and CKD. The younger the age of onset of hypertension is, the greater the risk of CKD.
No takes yet. Share an insight, caveat, or question.
Qiu et al. (2024) conducted a cross-sectional in Hypertension and Chronic Kidney Disease (n=30,613). Early-onset hypertension (age <35 years) vs. No hypertension was evaluated on Chronic kidney disease (eGFR <60 ml/min/1.73 m2 and/or UACR >30 mg/g) (OR 2.52, 95% CI 1.53-4.14, p=<0.001). Early-onset hypertension (age <35 years) was associated with a significantly greater risk of developing chronic kidney disease compared with the absence of hypertension (OR 2.52).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: