Key result
Early-onset hypertension (<45 years) was associated with the highest risk of incident atrial fibrillation (HR 3.18; 95% CI 1.74-5.82), with risk decreasing as onset age increased.
Why the study?
It was unknown whether the age at hypertension onset is associated with the risk of incident atrial fibrillation in the general population.
Does early age of hypertension onset increase the risk of incident atrial fibrillation in the general population?
Cohort (n=9,892)
Does early age of hypertension onset increase the risk of incident atrial fibrillation in the general population?
Early-onset hypertension (age <45 years) is associated with a significantly higher risk of incident atrial fibrillation and younger age of AF onset, suggesting a need for earlier AF surveillance in this population.
Supports earlier AF surveillance consideration in early-onset hypertension; leaves open causal confirmation and intervention effects.
We investigated whether age at hypertension (HTN) onset was associated with the risk of atrial fibrillation (AF) in the general population. This prospective longitudinal community-based cohort study included 9892 participants without AF at baseline, who underwent biennial electrocardiography for a median duration of 11.5 years. The participants were divided into five groups, consisting of a normotensive group (Group-N) and four HTN groups based on HTN onset age: <45 years (Group-H1); 45−54 years (Group-H2); 55−64 years (Group-H3); and ≥65 years (Group-H4). A multivariate Cox proportional hazards model showed that the presence of HTN at baseline was associated with higher AF risk (hazard ratio [HR], 1.93; 95% confidence interval [CI] 1.32−2.80). The participants in Group-H1 had the highest risk of AF (HR 3.18; CI 1.74−5.82), and the risk of AF decreased as HTN onset age increased across the four HTN groups (p for trend = 0.014). The AF onset age was significantly younger in participants in Group-H1 than in Groups-H2−H4. Early-onset HTN was associated with an increased risk of AF, and younger onset of AF in the general population. Surveillance for AF should be considered at a younger age in individuals with HTN.
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Lee et al. (2022) conducted a cohort in Hypertension (n=9,892). Early-onset hypertension (<45 years) vs. Normotensive group was evaluated on Incident atrial fibrillation (HR 3.18, 95% CI 1.74-5.82, p=0.014). Early-onset hypertension (<45 years) was associated with the highest risk of incident atrial fibrillation (HR 3.18; 95% CI 1.74-5.82), with risk decreasing as onset age increased.
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