Key result
New-onset overweight at 18-39 years is linked to ~38% higher incident hypertension risk.
Why the study?
The study was designed to examine the association between age at onset of overweight and incident hypertension.
Does younger age at onset of overweight increase the risk of incident hypertension compared to maintaining normal weight?
Cohort (n=9,484)
Does younger age at onset of overweight increase the risk of incident hypertension compared to maintaining normal weight?
Younger age at onset of overweight is associated with a significantly increased risk of developing hypertension, emphasizing the importance of early weight management.
Earlier overweight onset was associated with higher hypertension risk; hypothesis-generating for timed prevention trials.
OBJECTIVE: The aim of this study was to examine the association between age at onset of overweight and incident hypertension. METHODS: We analysed 4742 participants with new-onset overweight from the Kailuan study between 2006 and 2015 and and 4742 age-matched and sex-matched controls selected randomly from the same cohort but with normal weight. Participants were compared with respect to subsequent risk of hypertension, with sub-HR calculated with the Fine and Gray model, according to age of onset of overweight. RESULTS: Over a mean follow-up period of 5.17 years, 1642 overweight participants (34.6%) and 1293 normal-weight controls (27.3%) were subsequently diagnosed with hypertension. The median age at onset of overweight was 49.1 years. Compared with normal-weight controls, the multivariable-adjusted sub-HR for hypertension among participants with onset of overweight at 18-39 years of age, 40-49 years of age, 50-59 years of age and ≥60 years of age was 1.38 (95% CI 1.11 to 1.72), 1.27 (95% CI 1.09 to 1.49), 1.23 (95% CI 1.09 to 1.38) and 1.14 (95% CI 0.99 to 1.32), respectively. Onset of overweight in each age range was significantly associated with increased risk of hypertension, except for the group with onset at ≥60 years of age. The risk increased with each decade of attenuation of age at onset, peaking at 18-39 years of age. CONCLUSIONS: Younger age at onset of overweight across adulthood was associated with significantly increased risk of hypertension, with the highest relative risk among participants with onset of overweight at 18-39 years of age.
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Li et al. (2022) conducted a cohort in Overweight and incident hypertension (n=9,484). New-onset overweight vs. Normal weight was evaluated on Incident hypertension (HR 1.38, 95% CI 1.11 to 1.72). New-onset overweight was associated with increased risk of incident hypertension (34.6% vs 27.3%), with the highest risk among those with onset at 18-39 years of age (HR 1.38; 95% CI 1.11-1.72).
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