New-onset overweight was associated with increased risk of incident hypertension (34.6% vs 27.3%), with the highest risk among those with onset at 18-39 years of age (HR 1.38; 95% CI 1.11-1.72).
Cohort (n=9,484)
Does younger age at onset of overweight increase the risk of incident hypertension compared to maintaining normal weight?
Younger age at onset of overweight is associated with a significantly increased risk of developing hypertension, emphasizing the importance of early weight management.
Hazard Ratio: 1.38 (95% CI 1.11–1.72)
Absolute Event Rate: 34.6% vs 27.3%
OBJECTIVE: The aim of this study was to examine the association between age at onset of overweight and incident hypertension. METHODS: We analysed 4742 participants with new-onset overweight from the Kailuan study between 2006 and 2015 and and 4742 age-matched and sex-matched controls selected randomly from the same cohort but with normal weight. Participants were compared with respect to subsequent risk of hypertension, with sub-HR calculated with the Fine and Gray model, according to age of onset of overweight. RESULTS: Over a mean follow-up period of 5.17 years, 1642 overweight participants (34.6%) and 1293 normal-weight controls (27.3%) were subsequently diagnosed with hypertension. The median age at onset of overweight was 49.1 years. Compared with normal-weight controls, the multivariable-adjusted sub-HR for hypertension among participants with onset of overweight at 18-39 years of age, 40-49 years of age, 50-59 years of age and ≥60 years of age was 1.38 (95% CI 1.11 to 1.72), 1.27 (95% CI 1.09 to 1.49), 1.23 (95% CI 1.09 to 1.38) and 1.14 (95% CI 0.99 to 1.32), respectively. Onset of overweight in each age range was significantly associated with increased risk of hypertension, except for the group with onset at ≥60 years of age. The risk increased with each decade of attenuation of age at onset, peaking at 18-39 years of age. CONCLUSIONS: Younger age at onset of overweight across adulthood was associated with significantly increased risk of hypertension, with the highest relative risk among participants with onset of overweight at 18-39 years of age.
Li et al. (2022) conducted a cohort in Overweight and incident hypertension (n=9,484). New-onset overweight vs. Normal weight was evaluated on Incident hypertension (HR 1.38, 95% CI 1.11 to 1.72). New-onset overweight was associated with increased risk of incident hypertension (34.6% vs 27.3%), with the highest risk among those with onset at 18-39 years of age (HR 1.38; 95% CI 1.11-1.72).