Key result
Early-onset hypertension is a highly heritable trait that confers an increased risk for cardiovascular death and end-organ damage compared with late-onset hypertension.
Why the study?
To review the current evidence on age of hypertension onset, including its definition, correlates, heritability, and association with adverse outcomes, and propose a clinical implementation framework.
Assessing the age of hypertension onset could provide a feasible method for improving cardiovascular risk stratification and personalizing therapy, as early-onset hypertension carries a higher lifetime cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Supports intensified family surveillance for early-onset hypertension; leaves open whether genetic profiling refines risk stratification or management.
PURPOSE OF REVIEW: To review the current evidence on research related to age of hypertension onset-its definition, correlates, heritability, and association with adverse outcomes. We also propose a framework for implementing assessment of hypertension onset age into clinical practice. RECENT FINDINGS: Prior studies have used both objective measurements and self-report to determine age of hypertension onset or early-onset hypertension. Yet, no criterion for standard definition currently exists for either. Data from epidemiological and clinical studies demonstrate that early-onset hypertension is a highly heritable trait that confers an increased risk for cardiovascular death and end-organ damage compared with late-onset hypertension. Literature to date suggests that (parental) age of hypertension onset can be feasibly assessed for estimating (1) risk of future hypertension in non-hypertensive persons; and (2) the propensity for cardiovascular disease in individuals with established hypertension.
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Suvila et al. (2020) conducted a review in Hypertension. Early-onset hypertension vs. Late-onset hypertension was evaluated. Early-onset hypertension is a highly heritable trait that confers an increased risk for cardiovascular death and end-organ damage compared with late-onset hypertension.
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