Key result
Chronic nitrate therapy with isosorbide-5-mononitrate did not significantly affect neurohumoral status in patients with LV dysfunction after AMI, apart from a decrease in ANP.
Why the study?
Does isosorbide-5-mononitrate improve neurohumoral status in patients with left ventricular dysfunction following acute myocardial infarction?
RCT (n=92)
Double-blind
randomized
Does isosorbide-5-mononitrate improve neurohumoral status in patients with left ventricular dysfunction following acute myocardial infarction?
Long-term nitrate therapy does not significantly alter neurohumoral activation in patients with post-AMI left ventricular dysfunction treated with ACE inhibitors.
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Chronic isosorbide-5-mononitrate adds no neurohumoral benefit in ACE inhibitor-treated post-AMI LV dysfunction; confirms neutral effect on most activation markers.
Tingberg et al. (2006) conducted an RCT in Left ventricular dysfunction following acute myocardial infarction (n=92). Isosorbide-5-mononitrate vs. Placebo was evaluated on Neurohumoral status (plasma natriuretic peptides, epinephrine, norepinephrine, antidiuretic hormone, aldosterone, renin activity, substance P, neuropeptide Y-like immunoreactivity, calcitonin gene-related peptide, and vasoactive intestinal peptide). Chronic nitrate therapy with isosorbide-5-mononitrate did not significantly affect neurohumoral status in patients with LV dysfunction after AMI, apart from a decrease in ANP.
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