Key result
Regulation of cardiac muscle contractility is achieved through modulation of the spatio-temporal nature of intracellular Ca2+ signals operating in microdomains close to release sites.
This viewpoint highlights the importance of localized Ca2+ signaling in microdomains for the regulation of cardiac muscle contractility.
Highlights microdomain Ca2+ signaling for contractility control; extends mechanistic insights while leaving clinical translation open.
The myriad of intracellular signalling pathways involving intracellular Ca2+ means Ca2+ plays a role in everything from cellular metabolism to cell death. In heart muscle Ca2+ is primarily known for its role in cellular contraction. Regulation of cardiac muscle contractility is achieved through modulation of the spatio-temporal nature of intracellular Ca2+ signals, operating in areas of restricted diffusion or microdomains, close to Ca2+ release sites. This Viewpoint article briefly integrates experimental evidence in support of this concept.
No takes yet. Share an insight, caveat, or question.
Fowler et al. (2009) conducted a review in Cardiac muscle contractility. Intracellular Ca2+ signals was evaluated. Regulation of cardiac muscle contractility is achieved through modulation of the spatio-temporal nature of intracellular Ca2+ signals operating in microdomains close to release sites.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: