The peroxidase-halide-hydrogen peroxide system demonstrates potent virucidal activity against polio and vaccinia viruses, suggesting a potential role in host defense against certain viral infections.
Supports further investigation of innate antiviral mechanisms; does not inform clinical antiviral strategies.
Peroxidase (myeloperoxidase or lactoperoxidase), hydrogen peroxide, and a halide such as iodide, bromide, or chloride form a potent virucidal system that is effective against polio and vaccinia viruis, particularly at a low pH. The peroxidase-halide-hydrogen peroxide system may contribute to the host defense against certain viral infections.
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Belding et al. (1970) studied this question.
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