Key result
Resistance training increased left ventricle weight-to-body weight ratio by 8.5% (P<0.05) and upregulated AT1 receptor expression, an effect prevented by subhypotensive doses of losartan.
Why the study?
Does AT1 receptor blockade with losartan prevent resistance training-induced cardiac hypertrophy in rats?
Population
36 male Wistar rats
Comparison
Resistance training alone or combined with… vs Sedentary control rats
Design
Preclinical, divided into six groups
Follow-up
8 weeks
Authors
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Losartan may attenuate resistance training cardiac hypertrophy in rats; leaves open translation to human exercise-induced remodeling.
Does AT1 receptor blockade with losartan prevent resistance training-induced cardiac hypertrophy in rats?
p-value: p=<0.05
Resistance training-induced cardiac hypertrophy in rats is mediated by local activation of the renin-angiotensin system via AT1 receptor upregulation, and can be prevented by losartan.
Baraúna et al. (2008) studied Cardiac hypertrophy (n=36). Resistance training with or without losartan or high-salt diet vs. Control was evaluated on Left ventricle weight-to-body weight ratio increase (p=<0.05). Resistance training increased left ventricle weight-to-body weight ratio by 8.5% (P<0.05) and upregulated AT1 receptor expression, an effect prevented by subhypotensive doses of losartan.
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