Why the study?
Does AT1 blockade prevent physiological cardiac hypertrophy in adult rats subjected to chronic exercise conditioning?
Population
Adult rats subjected to an 8-week swimming program
Comparison
Angiotensin receptor 1 (AT1) antagonist L-158809 vs Untreated swimmers and matched sedentary controls
Design
Preclinical
Follow-up
8 weeks
Authors
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AT1 blockade does not prevent exercise LV hypertrophy in rats; leaves open RAS mediation of physiological cardiac growth in humans.
Does AT1 blockade prevent physiological cardiac hypertrophy in adult rats subjected to chronic exercise conditioning?
AT1 receptor blockade does not prevent physiological cardiac hypertrophy induced by chronic exercise in rats, indicating that the renin-angiotensin system does not mediate this adaptation.
Geenen et al. (1996) studied this question.
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