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March 1, 2009Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Local renin-angiotensin system regulates left ventricular hypertrophy induced by swimming training independent of circulating renin: a pharmacological study

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Why the study?

Does pharmacological blockade of the renin-angiotensin system reduce left ventricular hypertrophy induced by swimming training in female Wistar rats?

Population

Female Wistar rats (n=112)

Comparison

Enalapril maleate, losartan, or high salt diet… vs Implied untreated trained controls

Design

Preclinical

Follow-up

10 weeks

Authors

EOEdilamar Menezes de OliveiraMSMaurício S. SasakiMCMarcela Cerêncio

Discussion

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Overview

Rat data on RAS blockade in exercise LVH should not guide practice; extends local RAS role in physiological hypertrophy but requires human validation.

Structured PICO

Does pharmacological blockade of the renin-angiotensin system reduce left ventricular hypertrophy induced by swimming training in female Wistar rats?

P
Population
Female Wistar rats (n=112)
I
Intervention
Enalapril maleate (60 mg/kg/day), losartan (20 mg/kg/day), or high salt diet (1% NaCl) combined with swimming training protocols (T1: 60-min session, 5 days/week for 10 weeks; T2: progressive up to 3 times/day by 10th week)
C
Comparator
Implied untreated trained controls
O
Outcome
Left ventricular hypertrophy (left ventricular/body weight ratio, mg/g)surrogate

Physiological left ventricular hypertrophy induced by swimming training in rats is regulated by the local renin-angiotensin system independently of systemic circulating renin.

Cite This Study

Oliveira et al. (2009) studied this question.

synapsesocial.com/papers/6a80cbf59ec2426b2722bbfdhttps://doi.org/10.1177/1470320309102304
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Also Consider

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  1. 1AT<sub>1</sub> receptor participates in the cardiac hypertrophy induced by resistance training in rats2008 · 48 citations
  2. 2Swimming training induced sex-specific differences in cardiac hypertrophy and blood levels of the renin-angiotensin system2024
  3. 3Angiotensin receptor 1 blockade does not prevent physiological cardiac hypertrophy in the adult rat1996 · 29 citations
  4. 4Effects of Renin-Angiotensin System Blockade and Dietary Salt Intake on Left Ventricular Hypertrophy in Dahl Salt-Sensitive Rats.1998 · 19 citations
  5. 5Selective increase of angiotensin(1–7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training2008 · 74 citations