Key result
Regression of echocardiographic left ventricular hypertrophy or persistent normal mass in hypertension was associated with a reduction in total cardiovascular events (HR 0.54; 95% CI 0.35-0.84; P=0.007).
Why the study?
Does echocardiographic LVH regression reduce total cardiovascular events in hypertensive patients?
Population
2,449 hypertensive patients included in the meta-analysis, mean age range 48-66 years, 58% men, 1,900 with…
Comparison
Echocardiographic left ventricular hypertrophy… vs LVH persistence or LVH development
Design
Meta-analysis
Follow-up
3 to 9 years
Authors
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May support LVH regression as a hypertension treatment target; extends meta-analytic evidence linking mass reduction to lower CV risk.
Meta-Analysis (n=2,449)
Does echocardiographic LVH regression reduce total cardiovascular events in hypertensive patients?
Hazard Ratio: 0.54 (95% CI 0.35–0.84)
p-value: p=0.007
Regression of echocardiographic left ventricular hypertrophy in hypertensive patients is associated with a significant reduction in cardiovascular events.
Pierdomenico et al. (2010) conducted a meta-analysis in hypertension (n=2,449). Echocardiographic left ventricular hypertrophy (LVH) regression or persistent normal LV mass vs. LVH persistence or LVH development was evaluated on Total cardiovascular events (HR 0.54, 95% CI 0.35-0.84, p=0.007). Regression of echocardiographic left ventricular hypertrophy or persistent normal mass in hypertension was associated with a reduction in total cardiovascular events (HR 0.54; 95% CI 0.35-0.84; P=0.007).
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