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June 5, 2026In Silico Research in BiomedicineOpen Access

Mapping the regulatory landscape of the human GHRL promoter through integrative in- silico approaches

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Authors

LCLiliana Caporal-HernandezDODiego F. Ovalle-MarroquínCPCruz Nieves Rosa Patricia

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Overview

Integrative in silico analysis identifies regulatory elements in the GHRL promoter, suggesting histone modification-driven regulation.

Key Points

  • This research aims to identify and characterize the regulatory elements of the human GHRL promoter and their functional implications.
  • Conducted integrative in silico analyses of the human GHRL promoter sequences to identify transcription factor binding sites.
  • Utilized public datasets to assess conservation scores and integrate epigenomic profiles such as histone marks and chromatin accessibility.
  • Analyzed promoter architecture to highlight the presence of both canonical and non-canonical regulatory elements.
  • The GHRL promoter exhibits a complex architecture with both canonical motifs and high-density transcription factor binding sites.
  • Epigenetic analysis revealed significant enrichment of activating histone marks and chromatin accessibility, varying across developmental stages.
  • Functional enrichment analyses identified key pathways related to metabolic regulation and hormonal signaling.

Cite This Study

Caporal-Hernandez et al. (2026) studied this question.

synapsesocial.com/papers/6a22672f763171746d545f7chttps://doi.org/10.1016/j.insi.2026.100424
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