Key result
Administration of tranexamic acid and carbazochrome sodium sulfonate hydrate successfully controlled severe intramuscular bleeding and improved the DIC score in a patient with advanced prostate cancer.
Why the study?
Disseminated intravascular coagulation is the most frequent coagulation disorder associated with solid tumors, including prostate cancer, but intramuscular bleeding as an initial manifestation had not been previously reported.
Case Report (n=1)
Intramuscular bleeding can be a rare initial manifestation of prostate cancer-associated DIC with enhanced fibrinolysis, which can be managed with anti-fibrinolytic therapy and treatment of the underlying malignancy.
Answers are grounded in this paper and cite their sources.
May support anti-fibrinolytics in prostate cancer DIC bleeding; hypothesis-generating and requires prospective validation.
Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder associated with solid tumors, including prostate cancer. We herein report a 76-year-old man who suffered from intramuscular bleeding of the right gluteus maximus. Laboratory data showed a pattern of DICwith enhanced fibrinolysis, and a general examination led to the diagnosis of advanced prostate cancer with multiple bone metastases. To our knowledge, this is the first report describing intramuscular bleeding as an initial manifestation of prostate cancer with DIC with enhanced fibrinolysis.
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Takada et al. (2021) conducted a case report in Prostate cancer with disseminated intravascular coagulation (DIC) and enhanced fibrinolysis (n=1). Tranexamic acid and carbazochrome sodium sulfonate hydrate was evaluated on Improvement of DIC score and resolution of bleeding. Administration of tranexamic acid and carbazochrome sodium sulfonate hydrate successfully controlled severe intramuscular bleeding and improved the DIC score in a patient with advanced prostate cancer.
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