Key result
Prostate biopsy in metastatic prostate cancer triggers life-threatening DIC requiring massive transfusion and epsilon-aminocaproic acid.
Why the study?
DIC with excessive fibrinolysis in prostate cancer is a rare, life-threatening variant that can present with massive bleeding, reflecting shifts between procoagulant and anticoagulant pathway activation.
Design
Case report
Authors
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May warrant procedural caution in metastatic prostate cancer; leaves open risk-stratification and preventive strategies.
Case Report (n=1)
No
This case highlights the delicate balance of the coagulation cascade in prostate cancer-associated DIC, where treatment of excessive fibrinolysis can precipitate severe thromboembolic complications like DVT and paradoxical stroke.
Ghallab et al. (2022) conducted a case report in Prostate cancer with disseminated intravascular coagulation and excessive fibrinolysis (n=1). Diagnostic prostatic biopsy was evaluated on Development of disseminated intravascular coagulation with excessive fibrinolysis. A diagnostic prostatic biopsy in a patient with metastatic prostate cancer triggered life-threatening disseminated intravascular coagulation with excessive fibrinolysis, requiring massive transfusion and epsilon-aminocaproic acid.
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