Key result
Antegrade transseptal crossing enables successful ViV-TAVR for degenerated Perceval valves after failed retrograde attempts.
Why the study?
The sutureless Perceval bioprosthesis presents unique technical challenges during ViV-TAVR due to its supra-annular nitinol ring, lack of radiopaque markers, and potential difficulty with central crossing and device entrapment.
Case Report (n=2)
Antegrade transseptal crossing with arteriovenous loop formation may offer a safer and more reproducible approach for ViV-TAVR in degenerated Perceval valves compared to standard retrograde crossing.
Favorable ViV-TAVR outcomes via antegrade transseptal approach in degenerated Perceval valves are hypothesis-generating; prospective studies needed before practice change.
BACKGROUND: Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) is an established treatment option for bioprosthetic valve failure. The sutureless Perceval bioprosthesis presents unique technical challenges because of the valve's supra-annular nitinol ring, lack of radiopaque markers, and potential difficulty with central valve crossing and entrapment of devices within the supra-annular ring. CASE SUMMARY: We report 2 cases of Perceval degeneration managed with ViV-TAVR using balloon-expandable Edwards Sapien 3 Ultra valves. In the first case, standard retrograde crossing led to delivery system entrapment despite multiple conventional methods for assessing central crossing, requiring multiple complex bailout maneuvers including balloon-assisted displacement and TAVR delivery system snaring. In the second case, after failed central retrograde crossing, antegrade transseptal approach with arteriovenous loop formation enabled precise central crossing. After wire externalization via the femoral artery, standard retrograde TAVR delivery and successful valve deployment were performed without complication. Both patients experienced favorable outcome and symptom resolution at follow-up. TAKE-HOME MESSAGES: These cases highlight the importance of preprocedural planning, advanced imaging guidance, and alternative access and crossing strategies when performing ViV-TAVR in Perceval valves. The antegrade approach may be safer, is reproducible, and saves on procedure time.
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Kodali et al. (2026) conducted a case report in Perceval bioprosthesis degeneration (n=2). Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) was evaluated on Procedural success and symptom resolution. Valve-in-valve TAVR for degenerated Perceval valves was successfully performed in 2 cases, with an antegrade transseptal approach enabling precise central crossing after failed retrograde attempts.
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