Key result
A review of current knowledge indicates that risk factors for stroke and indications for antithrombotic agents in cardiomyopathy are similar to those of atrial fibrillation prior to the 1980s-1990s.
Why the study?
What is the role of antithrombotic drugs in preventing stroke in patients with cardiomyopathy or heart failure in sinus rhythm?
What is the role of antithrombotic drugs in preventing stroke in patients with cardiomyopathy or heart failure in sinus rhythm?
This review highlights the lack of adequate prospective randomized studies on the benefits of anticoagulation in patients with cardiomyopathy in sinus rhythm, emphasizing the urgent need for such trials.
Answers are grounded in this paper and cite their sources.
May not yet justify routine antithrombotics in sinus-rhythm cardiomyopathy; leaves open benefit of anticoagulation pending dedicated RCTs.
BACKGROUND: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. METHODS: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. RESULTS: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. CONCLUSION: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.
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Pullicino et al. (2008) conducted a review in Cardiomyopathy or Heart Failure in Sinus Rhythm. Oral Anticoagulation was evaluated on Risk of stroke. A review of current knowledge indicates that risk factors for stroke and indications for antithrombotic agents in cardiomyopathy are similar to those of atrial fibrillation prior to the 1980s-1990s.
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