Key result
Mechanical stress via stretching or hypotonic solution induced a long-lasting depression of tension in fatigued frog skeletal muscle fibres, indicating a fragile mechano-sensitive link in EC coupling.
Mechanical stress induces a long-lasting depression of tension in fatigued skeletal muscle fibers, suggesting a vulnerable mechano-sensitive link in excitation-contraction coupling.
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Hypothesis-generating for mechano-sensitive EC coupling in fatigue; leaves open relevance to mammalian or cardiac muscle.
Bruton et al. (1995) studied Excitation-contraction coupling in fatigued muscle fibres (n=49). Mechanical stress (stretching or hypotonic solution) vs. Initial tension level was evaluated on Tension depression and recovery. Mechanical stress via stretching or hypotonic solution induced a long-lasting depression of tension in fatigued frog skeletal muscle fibres, indicating a fragile mechano-sensitive link in EC coupling.
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