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March 1, 1998HypertensionOpen Access

Human Vascular Renin-Angiotensin System and Its Functional Changes in Relation to Different Sodium Intakes

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Why the study?

Do different sodium diets alter the metabolism of angiotensins through vascular tissue in normotensive healthy subjects?

Population

28 normotensive healthy control subjects

Comparison

Low and high sodium diets vs Normal sodium diet

Design

Cohort

Authors

MBMaria BoddiUniversity of FlorenceLPLoredana PoggesiSocietà Italiana di CardiologiaMCMirella CoppoAzienda Ospedaliero-Universitaria Careggi

Discussion

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Overview

Low-sodium intake suppresses vascular angiotensin formation; supports functional tissue RAS but leaves clinical relevance hypothesis-generating.

Structured PICO

Do different sodium diets alter the metabolism of angiotensins through vascular tissue in normotensive healthy subjects?

P
Population
28 normotensive healthy control subjects
I
Intervention
Low and high sodium diets
C
Comparator
Normal sodium diet
O
Outcome
Metabolism of angiotensins through vascular tissue (arterial-venous gradient of endogenous Ang I and Ang II, combined with 125I-Ang I and 125I-Ang II kinetics)surrogate

This study provides evidence for a functional tissue-based renin-angiotensin system in human vasculature that responds inversely to the circulating renin-angiotensin system under different sodium intakes.

Cite This Study

Boddi et al. (1998) studied this question.

synapsesocial.com/papers/6a227e77ffccceb004b72ef2https://doi.org/10.1161/01.hyp.31.3.836
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