Key result
Plasma renin of kidney origin is the major source of vascular functional renin and plays the determining role in the regulation of vascular angiotensin release in isolated rat hind legs.
Population
Isolated rat hind legs from rats subjected to various pretreatments
Design
Preclinical
Authors
Loading...
Kidney-derived plasma renin regulates vascular angiotensin release in rats; leaves open translation to human hypertension.
This preclinical study demonstrates that plasma renin of kidney origin, rather than locally produced components, is the primary determinant of vascular angiotensin release.
Kato et al. (1993) studied Regulation of the vascular renin-angiotensin system. Various manipulations (losartan, low sodium diet, nephrectomy, renin infusion) vs. Basal state was evaluated on Angiotensin release in the perfusate. Plasma renin of kidney origin is the major source of vascular functional renin and plays the determining role in the regulation of vascular angiotensin release in isolated rat hind legs.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: