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January 1, 1991Journal of Hypertension

Local angiotensin formation in hindlimbs of uremic hypertensive and renovascular hypertensive rats

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Population

Rats with 5/6 nephrectomy (5/6NX) and rats with one-kidney, one clip (1K1C) hypertension

Comparison

Isolated perfused rat hindquarter preparations… vs Sham operated animals

Design

Preclinical

Authors

MKMarian KuczeraHeidelberg UniversityKHKarl F. HilgersGeneral / Preventive / LipidsCLChristian Lisson

Discussion

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Overview

May implicate vascular angiotensin in uremic hypertension; hypothesis-generating and requires human confirmation before clinical consideration.

Key Points

  • This research aims to explore the vascular renin-angiotensin system in renal hypertension with and without renal insufficiency.
  • Isolated perfused rat hindquarter preparations were utilized for the study.
  • Rats with 5/6 nephrectomy (5/6NX) and one-kidney, one clip (1K1C) hypertension were compared to sham-operated groups.
  • Angiotensin peptides were analyzed using high-performance liquid chromatography and radioimmunoassay.
  • Plasma angiotensin II was lower and blood pressure was higher in 5/6NX and 1K1C rats compared to sham rats.
  • Angiotensin II degradation was significantly lower in 5/6NX rats (27.6%) versus sham rats (53.9%), P<0.05.
  • Renin-induced angiotensin release was significantly higher in 5/6NX compared to sham rats, while 1K1C showed no significant difference.

Structured PICO

P
Population
Rats with 5/6 nephrectomy (5/6NX) and rats with one-kidney, one clip (1K1C) hypertension
I
Intervention
Isolated perfused rat hindquarter preparations to study angiotensin formation and metabolism
C
Comparator
Sham operated animals
O
Outcome
Angiotensin formation and metabolism (including plasma angiotensin II, plasma angiotensinogen, spontaneous release of angiotensin I and II, angiotensin I conversion, renin-induced angiotensin release, and angiotensin II degradation)surrogate

In chronic uremic hypertension models, vascular angiotensin formation is increased and degradation is decreased, suggesting vascular angiotensin may contribute to elevated blood pressure in chronic renal failure.

Cite This Study

Kuczera et al. (1991) studied this question.

synapsesocial.com/papers/6a70836dac440176ef292deahttps://doi.org/10.1097/00004872-199101000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Augmented Blood Pressure Response to Chronic Angiotensin II Infusion in Partially Nephrectomized Rats.1993
  2. 2Angiotensin II control of the renal microcirculation in rats with reduced renal mass1990 · 62 citations
  3. 3Angiotensin-(1–7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy2010 · 74 citations
  4. 4Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats2016 · 25 citations
  5. 5Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1–7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats2011 · 74 citations