Key result
Angiotensin II (10 nM) significantly enhanced the pressor effects of sympathetic nerve stimulation at 1 and 10 Hz by 42% and 35%, respectively, independent of direct vasoconstrictor activity.
Why the study?
Does Angiotensin II facilitate noradrenergic transmission in the vascular bed to skeletal muscle in a rat hind limb model?
Population
Isolated, perfused rat hind limb preparation with electrically stimulated lumbar sympathetic trunk
Comparison
Angiotensin II (10 nM) perfusion vs Vasopressin perfusion or baseline/no peptide
Design
Preclinical
Authors
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Ang II augments sympathetic vascular responses in rat hind limb; leaves open relevance to human hypertension.
Does Angiotensin II facilitate noradrenergic transmission in the vascular bed to skeletal muscle in a rat hind limb model?
Angiotensin II facilitates noradrenergic transmission in skeletal muscle resistance vessels independent of its direct vasoconstrictor activity.
Hilgers et al. (1993) studied this question. Angiotensin II vs. Vasopressin / artificial medium was evaluated on Pressor response to nerve stimulation. Angiotensin II (10 nM) significantly enhanced the pressor effects of sympathetic nerve stimulation at 1 and 10 Hz by 42% and 35%, respectively, independent of direct vasoconstrictor activity.
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