Population
Sprague-Dawley and Wistar rats (normal and sodium-restricted models)
Comparison
Angiotensin II application, 7-day intravenous… vs Normal diet vs sodium-restricted diet; baseline…
Design
Preclinical
Follow-up
7 days (for chronic infusion)
Authors
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May blunt central Ang II facilitation of norepinephrine release in low-sodium states; hypothesis-generating for brainstem sympathetic control in humans.
Low sodium diets may alter the facilitation of norepinephrine release by Angiotensin II through interactions with the renin-angiotensin system in central cardiovascular regulatory areas.
Meldrum et al. (1984) studied this question.
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