March 1, 1986Journal of Biological ChemistryOpen Access

Regulation of renin angiotensins by gonadotropic hormones in cultured murine Leydig tumor cells. Release of angiotensin but not renin.

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Population

cloned and cultured mouse Leydig tumor cell line (MA-10)

Design

Preclinical

Authors

KPKailash N. PandeyTulane University TITadashi InagamiHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

No immediate clinical implications; leaves open gonadotropin modulation of testicular RAS in vivo.

Structured PICO

Population

cloned and cultured mouse Leydig tumor cell line (MA-10)

Intervention

Treatment with bovine luteinizing hormone (bLH, 100 ng/ml) or human chorionic gonadotropin (hCG, 25 ng/ml)

Outcome

synthesis and subsequent release of the components of the intracellular renin-angiotensin system (angiotensin I, angiotensin II, and renin)surrogate

In cultured murine Leydig tumor cells, gonadotropic hormones stimulate the intracellular renin-angiotensin system, leading to the secretion of angiotensins rather than renin.

Cite This Study

Pandey et al. (1986) studied this question.

synapsesocial.com/papers/6a227e80ffccceb004b72f0e https://doi.org/10.1016/s0021-9258(17)35604-1

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Regulation of renin angiotensins by gonadotropic hormones in cultured murine Leydig tumor cells. Release of angiotensin but not renin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of renin angiotensins by gonadotropic hormones in cultured murine Leydig tumor cells. Release of angiotensin but not renin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider