Population
Cloned and cultured Leydig tumor cells (designated MA-10)
Comparison
Treatment with bovine LH (bLH), hCG, or (Bu)2cAMP vs Control (untreated cells)
Design
Preclinical
Follow-up
up to 8-9 hours
Authors
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Supports gonadotropin-driven renin induction in Leydig cells; leaves open extra-renal renin contributions to human physiology.
Gonadotropic hormones (bLH, hCG) and cAMP induce renin activity in cultured Leydig tumor cells via de novo protein and RNA synthesis.
Pandey et al. (1985) studied this question.
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