Key result
Treatment with ACE inhibitors revealed angiotensin I-like immunoreactivity in juxtaglomerular cells, supporting an intracellular mechanism for angiotensin II formation.
Population
Rat kidney model
Comparison
Angiotensin-converting enzyme inhibitors vs Normal rat kidney (untreated)
Design
Preclinical
Authors
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May support intracellular RAS in kidney; leaves open relevance to human ACE inhibitor therapy.
Demonstrates the existence of an intracellular renin-angiotensin system in juxtaglomerular cells, distinct from the circulating system.
Naruse et al. (1982) studied this question. ACE inhibitors (MK-421 or captopril) vs. Normal rat kidney (untreated) was evaluated on Presence of AI-like immunoreactivity in juxtaglomerular cells. Treatment with ACE inhibitors revealed angiotensin I-like immunoreactivity in juxtaglomerular cells, supporting an intracellular mechanism for angiotensin II formation.
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