Key result
Angiotensin II immunoreactivity was found to coexist with renin in the epithelioid granular cells of the afferent vessel of the glomerulus in rats, suggesting intracellular production of AII.
Population
Rats (kidneys perfused with fixative)
Design
Preclinical
Authors
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Should not alter clinical renin-angiotensin blockade; leaves open intrarenal AII mechanisms in humans.
Demonstrates intracellular synthesis of Angiotensin II in juxtaglomerular cells, suggesting a local paracrine mechanism for regulating glomerular vessel tone.
Celio et al. (1981) studied this question. Immunohistochemical processing with antisera against renin and Angiotensin II was evaluated on Coexistence of Angiotensin II and renin immunoreactivity in juxtaglomerular epithelioid granular cells. Angiotensin II immunoreactivity was found to coexist with renin in the epithelioid granular cells of the afferent vessel of the glomerulus in rats, suggesting intracellular production of AII.
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