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July 1, 1980HypertensionOpen Access

Blood pressure responses of conscious normotensive and spontaneously hypertensive rats to intracerebroventricular and peripheral administration of captopril.

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Why the study?

Does intracerebroventricular captopril reduce blood pressure in spontaneously hypertensive rats?

Population

Conscious spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WK) rats

Comparison

Intracerebroventricular injection of captopril vs Intracerebroventricular injection of vehicle…

Design

Preclinical

Follow-up

7 hours

Authors

JHJ. S. HutchinsonAugusta UniversityFMF. A. O. MendelsohnCourtauld Institute of ArtADA. E. DoyleVictor Chang Cardiac Research Institute

Discussion

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Implication

Central captopril selectively lowers BP in SHR models; hypothesis-generating for central RAS targeting in human hypertension.

Key Points

  • The study aims to compare the blood pressure responses of normotensive and spontaneously hypertensive rats to captopril administered via different routes.
  • Intracerebroventricular injection of captopril (2 mg/kg) administered to conscious rats
  • Comparison of blood pressure response between spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
  • Measurement of plasma renin activity (PRA) in both SHR and WKY rats
  • Intracerebroventricular captopril significantly lowered blood pressure in SHR over several hours
  • No significant effect on blood pressure in WKY rats after the same intracerebroventricular injection
  • PRA levels were similar in both normotensive and hypertensive rats, indicating potential biochemical differences.

Structured PICO

Does intracerebroventricular captopril reduce blood pressure in spontaneously hypertensive rats?

P
Population
Conscious spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WK) rats
I
Intervention
Intracerebroventricular injection of captopril (2 mg/kg)
C
Comparator
Intracerebroventricular injection of vehicle; intravenous injection of captopril (2 mg/kg); normotensive Wistar-Kyoto rats
O
Outcome
Blood pressure (BP) responsesurrogate

Central administration of captopril lowers blood pressure in spontaneously hypertensive rats but not normotensive rats, suggesting biochemical differences in the brain renin-angiotensin system.

Cite This Study

Hutchinson et al. (1980) studied this question.

synapsesocial.com/papers/6a227e80ffccceb004b72f18https://doi.org/10.1161/01.hyp.2.4.546

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Propranolol on Blood Pressure and Plasma Renin Activity in the Spontaneously Hypertensive Rat1974 · 56 citations
  2. 2Renin-angiotensin system in spontaneously hypertensive rats1976 · 105 citations
  3. 3Effects of an Orally Active Converting-Enzyme Inhibitor, SQ 14225, on Pressor Responses to Angiotensin Administered into the Brain Ventricles of Spontaneously Hypertensive Rats1979 · 44 citations
  4. 4Neuroendocrine components in the regulation of blood pressure and renin secretion.1979 · 39 citations
  5. 5Separation of dog brain renin-like activity from acid protease activity.1979 · 50 citations